Large retroperitoneal lymphadenopathy and increased risk of venous thromboembolism in patients receiving first-line chemotherapy for metastatic germ cell tumors: A study by the global germ cell cancer group (G3).

Metastatic germ cell tumor (mGCT) patients receiving chemotherapy have increased risk of life-threatening venous thromboembolism (VTE). Identifying VTE risk factors may guide thromboprophylaxis in this highly curable population.

Data were collected from mGCT patients receiving first-line platinum-based chemotherapy at 22 centers. Predefined variables included International Germ Cell Cancer Collaborative Group (IGCCCG) risk classification, long-axis diameter of largest retroperitoneal lymph node (RPLN), Khorana score, and use of indwelling vascular access device (VAD). VTE occurring at baseline, during chemotherapy and within 90 days, was analyzed.

Data from 1135 patients were collected. Median age was 31 years (range 10-74). IGCCCG risk was 64% good, 20% intermediate, and 16% poor. VTE occurred in 150 (13%) patients. RPLN >3.5 cm demonstrated highest discriminatory accuracy for VTE (AUC 0.632, P < .001) and was associated with significantly higher risk of VTE in univariable analysis (22% vs 8%, OR 3.0, P < .001) and multivariable analysis (OR 1.8, P = .02). Other significant risk factors included, Khorana score ≥3 (OR 2.6, P = .008) and VAD use (OR 2.7, P < .001).

Large RPLN and VAD use are independent risk factors for VTE in mGCT patients receiving chemotherapy. VAD use should be minimized in this population and thromboprophylaxis might be considered for large RPLN.

Cancer medicine. 2019 Nov 12 [Epub ahead of print]

Ben Tran, Jose M Ruiz-Morales, Enrique Gonzalez-Billalabeitia, Anna Patrikidou, Eitan Amir, Christoph Seidel, Carsten Bokemeyer, Christian Fankhauser, Thomas Hermanns, Alexey Rumyantsev, Alexey Tryakin, Margarida Brito, Aude Fléchon, Edmond Michael Kwan, Tina Cheng, Daniel Castellano, Xavier Garcia Del Muro, Anis A Hamid, Margaret Ottaviano, Giovannella Palmieri, Robert Kitson, Alison Reid, Daniel Y C Heng, Philippe L Bedard

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia., Tom Baker Cancer Centre, Calgary, AB, Canada., Hospital Universitario Morales Meseguer - IMIB, UCAM, Murcia, Spain., Royal Marsden Hospital, London, UK., Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada., Department of Oncology, Hematology, BMT with Section Pneumology, Hubertus Wald Tumorzentrum, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., University Hospital Zurich, University of Zurich, Zurich, Switzerland., NN Blokhin Russian Cancer Research Centre and Research Institute of Oncology at BSMU, Moskva, Russia., Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal., Centre Léon Bérard, Lyon, France., Hospital Universitario 12 de Octubre, Madrid, Spain., Institut Catala d'Oncologia, Idibell, University of Barcelona, Barcelona, Spain., Olivia Newton John Cancer, Wellness and Research Centre, Heidelberg, Vic., Australia., CRTR Rare Tumors Reference Center, Università Degli Studi di Napoli Federico II, Napoli, Italy.