Somatic Transformation in Metastatic Testicular Germ Cell Tumours - A Different Disease Entity.

The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation.

A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew's Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET).

The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%.

Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.

Anticancer research. 2019 Sep [Epub]

Anand Sharma, Constantine Alifrangis, Marina Milic, Marcia Hall, Nikhil Vasdev, Peter Wilson, Andrew Gogbashian, David Hrouda, Daniel Berney, Jonathan Shamash

Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, U.K. ., Department of Oncology, St Bartholomew's Hospital, London, U.K. ., Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, U.K., Department of Urology and Surgery, Lister Hospital, East and North Herts NHS Trust, Stevenage, U.K., Department of Oncology, St Bartholomew's Hospital, London, U.K., Department of Radiology, Mount Vernon Cancer Centre, Paul Strickland Scanner Centre, Northwood, U.K., Department of Urology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, U.K., Department of Histopathology, Barts Cancer Institute, London, U.K.