Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis.

To estimate association between androgen receptor (AR) gene polymorphisms and testicular germ cell tumor (TGCT) susceptibility.

Systematic search of studies on the association between AR gene polymorphisms and TGCT susceptibility was conducted. Odds ratios and 95% confidence intervals were used to pool effect size.

For CAG repeat, no evidence was found for association between (>25 vs. ≤25), (>25 vs. 21-25), (<21 vs. 21-25), (others vs. 21-25), (>23 vs. ≤23), (<21 vs. ≥21), (<21 vs. ≥21)'s some subgroups and TGCT susceptibility, which showed stability. In (>24 vs. ≤24), (>24 vs. 21-24), (<21 vs. 21-24), and (others vs. 21-24) and almost all of their subgroups, increased TGCT risk was found without sensitivity analysis. For GGN, no statistical change of TGCT risk was found in (<23 vs. ≥23), (<23 vs. 23), which showed stability. For single nucleotide polymorphism (SNP) rs6152 G > A, rs1204038 G > A and rs2361634 A > G, no statistical change was found without sensitivity analysis.

GGN repeat number <23 may not be associated with TGCTs susceptibility. However, there was insufficient data to fully confirm association in GGN repeat number >23, CAG repeat number, SNP rs6152, rs1204038, and rs2361634.

Journal of cancer research and therapeutics. 2019 Mar [Epub]

Jiaxuan Qin, Ni Cui, Ruida Hou, Tie Liu, Hongyan Sun, Yi Liu, Lei Wang, Jinsong Ni, Xinquan Gu

Department of Urology Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China., Department of Clinical Medicine, Bethune Medical School, Jilin University, Changchun, Jilin, China., Department of Tissue Bank, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China., Department of Pathology, The First Clinical Hospital of Jilin University, Changchun, Jilin, China.

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