Outcome of Critically Ill Patients with Testicular Cancer

To evaluate the clinical characteristics and outcomes of critically ill patients with testicular cancer (TC) admitted to an oncological intensive care unit (ICU).

This was a prospective observational study. There were no interventions.

During the study period, 1,402 patients with TC were admitted to the Department of Oncology, and 60 patients (4.3%) were admitted to the ICU. The most common histologic type was nonseminomatous germ cell tumors (55/91.7%). The ICU, hospital, and 6-month mortality rates were 38.3%, 45%, and 63.3%, respectively. The Cox multivariate analysis identified the white blood cells count (HR = 1.06, 95% CI = 1.01-1.11, and P = 0.005), ionized calcium (iCa) level (HR = 1.23, 95% CI = 1.01-1.50, and P = 0.037), and 2 or more organ failures during the first 24 hours after ICU admission (HR = 3.86, 95% CI = 1.96-7.59, and P < 0.001) as independent predictors of death for up to 6 months.

The ICU, hospital, and 6-month mortality rates were 38.3%, 45%, and 63.3%, respectively. The factors associated with an increased 6-month mortality rate were white blood cells count, iCa level, and 2 or more organ failures during the first 24 hours after ICU admission.

BioMed research international. 2017 Oct 26 [Epub]

Silvio A Ñamendys-Silva, Mireya Barragán-Dessavre, Andoreni R Bautista-Ocampo, Francisco J García-Guillén, Bertha M Córdova-Sánchez, Edgar Constantino-Hérnandez, Paulina Correa-García, Octavio González-Chon, Angel Herrera-Gómez

Department of Critical Care Medicine, Instituto Nacional de Cancerología, 14080 Mexico City, Mexico., Department of Critical Care Medicine, Fundación Clínica Médica Sur, 14050 Mexico City, Mexico.

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