Evaluation of Factors Affecting Metastasis for Renal Cell Carcinoma Based on Current Guidelines in Japan

To analyze the suitability for metastasis evaluation of each pathologic item on the Fourth Edition of the General Rule for Clinical and Pathologic Studies on Renal Cell Carcinoma in Japan.

We retrospectively examined 457 cases of renal operation after 2011 using the current edition of the guidelines.

The mean postoperative follow-up period was 25.3 months. Radical nephrectomy was performed in 264 cases, whereas partial nephrectomy was performed in 193 cases. Including the 33 cases discovered after operation, the overall number of metastatic cases was 68 (14.9%). Using the current edition of the guidelines, the items of histologic grade, morphology of tumor invasion, tumor pseudocapsule, and intrarenal metastasis were all correlated with distant metastasis.

This is the first report showing that each item on the current Japanese guidelines for renal cell cancer was useful for predicting metastasis.

Anticancer research. 2017 Sep [Epub]

Yoshifui Kadono, Shohei Kawaguchi, Takahiro Nohara, Kazuyoshi Shigehara, Kazutaka Narimoto, Kouji Izumi, Hiroko Ikeda, Hiroshi Yaegashi, Tohru Miyagi, Takao Nakashima, Chikashi Seto, Atsushi Mizokami

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan ., Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan., Department of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa, Japan., Department of Urology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan., Department of Urology, Toyama Prefectural Central Hospital, Toyama, Japan.

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