Clinical predictors of the estimated glomerular filtration rate 1 year after radical nephrectomy in Japanese patients

To evaluate renal function 1 year after radical nephrectomy (RN) for renal cell carcinoma, the preoperative predictors of postnephrectomy renal function were investigated by sex, and equations to predict the estimated glomerular filtration rate (eGFR) 1 year after RN were developed.

A total of 525 patients who underwent RN between May 2007 and August 2011 at Tohoku University Hospital and its affiliated hospitals were prospectively evaluated. Overall, 422 patients were analyzed in this study.

Independent preoperative factors associated with postnephrectomy renal function were different in males and females. Preoperative eGFR, age, tumor size, and body mass index (BMI) were independent factors in males, while tumor size and BMI were not independent factors in females. The equations developed to predict eGFR 1 year after RN were: Predicted eGFR in males (mL/min/1.73 m(2))=27.99-(0.196×age)+(0.497×eGFR)+(0.744×tumor size)-(0.339×BMI); and predicted eGFR in females=44.57-(0.275×age)+(0.298×eGFR). The equations were validated in the validation dataset (R(2)=0.63, p<0.0001 and R(2)=0.31, p<0.0001, respectively).

The developed equations by sex enable better prediction of eGFR 1 year after RN. The equations will be useful for preoperative patient counseling and selection of the type of surgical procedure in elective partial or RN cases.

Investigative and clinical urology. 2017 Jun 27 [Epub]

Shuichi Shimada, Hideo Saito, Yoshihide Kawasaki, Shinichi Yamashita, Hisanobu Adachi, Narihiko Kakoi, Takashige Namima, Masahiko Sato, Atsushi Kyan, Koji Mitsuzuka, Akihiro Ito, Takuhiro Yamaguchi, Yoichi Arai

Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan., Department of Urology, Miyagi Cancer Center, Natori, Japan., Department of Urology, Tohoku Rosai Hospital, Sendai, Japan., Department of Urology, Hachinohe City Hospital, Hachinohe, Japan., Department of Urology, Shirakawa Kosei General Hospital, Shirakawa, Japan., Division of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan.

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