Prognostic Value of Vascular Endothelial Growth Factor A in the Prediction of the Tumor Aggressiveness in Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (CCRCC) is the most predominant renal tumour with unpredictable tumour behaviour. The aim of the study is to investigate the prognostic value of vascular endothelial growth factor A (VEGF-A) expression in CCRCC and to correlate it with other histological parameters as well as with patient's survival.

Tumour blocks were taken from 40 patients with histopathology diagnosis of CCRCC and tissue block from 20 normal kidneys as a control group were examined using the immuno-histochemical staining for VEGF-A.

The VEGF A expression in CCRCC was significantly higher than in the normal kidney tissues (U' = 720, P < 0.0001). VEGF A expression values in CCRCC were positively correlated with Disease Free Survival (r = 0.335, P = 0.034) and the tumor necrosis degree (r = 0.181, P = 0.262). VEGF-A expression values in CCRCC did not correlate with CD 31 expression (r = -0.09, P = 0.549), and Progression Free Survival (r = -0.07, P = 0.838). VEGF A expression values in CCRCC were negatively correlated with the tumor nuclear grade (r = -0.161, P = 0.318); the pathological tumor stage (r = -0.371, P = 0.018); the tumor size (r = -0.361, P = 0.022); the degree of tumor hemorrhage (r = -0.235, P = 0.143); and Cancer Specific Survival (r = -0.207, P = 0.713).

VEGF-A expression can be used to stratify advanced and metastatic CCRCC patients into low-benefit and high-benefit groups. Based on this study outcome it would be useful to perform IHC staining for VEGF-A expression in all patients with advanced and metastatic CCRCC.

Open access Macedonian journal of medical sciences. 2017 Apr 10*** epublish ***

Fahredin Veselaj, Suzana Manxhuka-Kerliu, Arber Neziri, Labinot Shahini, Shefki Xharra, Liridon Selmani, Lloreta Kerliu, Floren Kavaja

Clinic of Urology, UCC of Kosovo, Prishtina, Kosovo., Department of Pathology, UCC of Kosovo, Prishtina, Kosovo., Regional Hospital, Prizren, Kosovo., Massachusetts College of Pharmacy and Health Sciences (MCPHS), 179 Longwood Avenue, Boston, MA 02115, USA., Clinic of Surgery, UCC of Kosovo, Prishtina, Kosovo.

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