Hemodialysis does not impact axitinib exposure: clinical case of a patient with metastatic renal cell carcinoma

Axitinib is approved with indication in patients with advanced renal cell carcinoma (RCC). Due to the localization of this cancer, physicians sometimes have to deal with hemodialyzed patients. Data exploring hemodialysis (HD) impact on axitinib pharmacokinetic (PK) or safety are lacking. To date, no data have been published on that problematic. This is the first publication discussing the assessment of axitinib PK for a patient undergoing HD. Our results suggest that there is no influence of HD on axitinib blood concentration. Interestingly, the membranes used are common and represent around 90% of the membranes used in routine for HD. Our data are also reassuring both from activity and from safety perspectives. In that case, axitinib administered at a dose of 6 mg twice a day was well tolerated and allowed 12 months of disease control. These results are in line with previous publications discussing other anti-angiogenic tyrosine kinase inhibitors pharmacokinetics, safety and activity among patients with metastatic RCC undergoing hemodialysis.

Cancer chemotherapy and pharmacology. 2017 Apr 27 [Epub ahead of print]

Antoine Thiery-Vuillemin, Emeline Orillard, Guillaume Mouillet, Fabien Calcagno, Nadège Devillard, Stéphane Bouchet, Bernard Royer

Oncologie, CHU Besançon, 25030, Besançon cedex, France. ., Oncologie, CHU Besançon, 25030, Besançon cedex, France., Nephrology Unit, CHU Besançon, 25030, Besançon cedex, France., Pharmacology Unit, CHU Pellegrin, Bordeaux, France., INSERM, UMR1098, 25020, Besançon cedex, France.