Activity of chemokines in prostate and renal tumors and their potential role as future therapeutic targets

Chemokines are a class of low-molecular-weight proteins that induce chemotaxis and are implicated in the modulation of angiogenesis. The imbalance among angiogenic and antiangiogenic chemokines can promote the development of several conditions, including chronic inflammation, dysplastic transformation and cancer. In this review, we describe the activity and clinical significance of chemokines in prostate and renal tumors and provide an update on ongoing studies in this setting.

Future oncology (London, England). 2017 Feb 02 [Epub ahead of print]

Alessia Cimadamore, Marina Scarpelli, Francesco Piva, Francesco Massari, Silvia Gasparrini, Andrea Doria, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi

Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy., Department of Specialist Clinical & Odontostomatological Sciences, Università Politecnica delle Marche, Ancona, Italy., Division of Oncology, S Orsola-Malpighi Hospital, Bologna, Italy., Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Department of Surgery & Pathology, Faculty of Medicine, Cordoba University Medical School, Cordoba, Spain.