[Prognostic factors for metastatic renal cell carcinoma treated with second-line targeted therapies]

To assess the prognostic value of clinical and biological features in patients treated with second-line targeted therapies (TT) for a metastatic renal cell carcinoma (mRCC).

A retrospective study was performed including 60patients treated with second-line TT from 2006 to 2013.

Clinical and biological features were collected, including TT-induced toxicities, Heng and MSKCC prognostic scores, and renal function. Overall survival (OS) and progression-free survival (PFS) were assessed using univariate and multivariate analysis.

The median age was 61years [39-81]. MSKCC and Heng scores were significantly prognostic for OS and PFS (P

Our results suggested that renal function impairment and TT-induced toxicities in the second line of treatment for mRCC have a potential prognostic interest as it had previously been reported for the first line of TT.

5.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2015 Oct 08 [Epub ahead of print]

J D Rebibo, C Pfister, A Guiwerc, G Defortescu, S Gouerant, F Di Fiore, F-X Nouhaud

Service d'urologie et transplantation, centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France. , Service d'urologie et transplantation, centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France; Équipe de recherche d'oncologie normande (IRON), centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France. , Service d'urologie et transplantation, centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France. , Service d'urologie et transplantation, centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France. , Unité d'oncologie urologique et digestive, centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France; Service d'oncologie médicale, centre Henri-Becquerel, rue d'Amiens, 76000 Rouen, France. , Équipe de recherche d'oncologie normande (IRON), centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France; Unité d'oncologie urologique et digestive, centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France; Service d'oncologie médicale, centre Henri-Becquerel, rue d'Amiens, 76000 Rouen, France. , Service d'urologie et transplantation, centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France; Équipe de recherche d'oncologie normande (IRON), centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France; Unité d'oncologie urologique et digestive, centre hospitalier et universitaire de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.  

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