Long-Term Risk of Cancer in Survivors of Pediatric ESRD

ESRD is associated with an increased risk of malignancies. We analyzed the incidence of cancer in patients with pediatric ESRD after long-term follow-up.

All Dutch patients born before 1979 who were transplanted at age We explored type and incidence of malignancies in patients compared with the general population using the National Cancer Registry.

After a median of 25. 3 years (1. 3-37. 8) of transplantation and at a median age of 33. 5 years old (11. 0-49. 0), 105 primary malignancies had occurred in 54 of 249 patients. Among them, cutaneous squamous cell carcinoma was most frequent. Patients ages 25-30 years old had developed 16. 5 times (95% confidence interval, 7. 9 to 34. 6) as many de novo tumors and 991 times (95% confidence interval, 313 to 3137) as many de novo cutaneous squamous cell carcinomas as their general population counterparts; in survivors ages 45-50 years old, these numbers were 81. 5 (95% confidence interval, 50. 7 to 131. 1) and 2610 (95% confidence interval, 1596 to 4267), respectively. Cumulative incidence competing risk analysis showed that, after 30 years of transplantation, 41% of the survivors had developed cancer; 31% had developed a second de novo cancer

Cancer is highly prevalent among patients with pediatric ESRD after 25. 3 years of transplantation, with a high rate of recurrence.

Clinical journal of the American Society of Nephrology : CJASN. 2015 Oct 01 [Epub ahead of print]

Sophie Ploos van Amstel, Judith L Vogelzang, Marcus V Starink, Kitty J Jager, Jaap W Groothoff

Department of Paediatric Nephrology, Emma Children's Hospital and. , Department of Paediatric Nephrology, Emma Children's Hospital and J. L. Vogelzang@amc. uva. nl. , Department of Dermatology, Academic Medical Center, Amsterdam, The Netherlands; and. , European Renal Association-European Dialysis and Transplant Association, Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. , Department of Paediatric Nephrology, Emma Children's Hospital.