BERKELEY, CA (UroToday.com) - In our paper, we found an association between lymphovascular invasion (LVI) and disease-free and cancer-specific survival on univariate -- but not multivariate -- analysis in a cohort of 419 patients with non-metastatic clear cell renal cell carcinoma (ccRCC).
In 333 patients with organ confined (pT1-2), non-metastatic ccRCC, LVI was a significant predictor of disease-free (HR 4.0, p=0.026) and cancer-specific survival (HR 12.7, p=0.01) on multivariate analysis, controlling for tumor size/stage, and Fuhrman grade. Patients who had organ-confined, non-metastatic ccRCC with positive LVI had similar disease-free (p=0.957) and cancer-specific survival (p=0.799) to patients with locally advanced tumors (pT3-pT4, N any, M0).
These findings indicate that presence of LVI in those patients with otherwise low-risk, organ-confined disease confers oncologic outcomes similar to those with traditional high-risk pathologic features. If confirmed, future revisions to the tumor-node-metastasis staging system may incorporate LVI into the prognostic algorithm of patients with RCC.
Michael Belsante, MD as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.
Department of Urology, UT Southwestern Medical Center, Dallas, TX