Significant impact of age at diagnosis on the prognosis of Japanese patients with pT1 renal cell carcinoma following surgical resection - Abstract

Division of Urology, Kobe University Graduate School of Medicine, Kobe.

Department of Urology, Hyogo Cancer Center, Akashi; Department of Urology, Himeji Red Cross Hospital, Himeji; Department of Urology, Hyogo Prefectural Amagasaki Hospital, Amagasaki, Japan.

 

 

Study Type - Prognosis (individual cohort) Level of Evidence 2b.

What's known on the subject? and What does the study add? Several parameters significantly associated with the prognosis of patients with small venal cell carcinoma (RCC) have been reported; however, the outcomes described in such studies are not totally consistent, and the majority of these studies were based on the data from Western populations. Age of diagnosis is a significant predictor of disease recurrence as well as overall survivals in Japanese patients with pT1 RCC following surgical resection; therefore, intensive follow-up of older patients is necessary even for those with pT1 RCC.

To retrospectively review oncological outcomes following surgical resection in Japanese patients with pT1 renal cell carcinoma (RCC).

The present study included a total of 832 consecutive Japanese patients who underwent either radical or partial nephrectomy and were subsequently diagnosed as having localized pT1 RCC. The significance of several clinicopathological factors in their postoperative outcomes was analysed.

The median (range) age of the 832 patients was 66 (31-90) years. Radical and partial nephrectomies were performed for 710 patients (85.3%) and 122 patients (14.7%), respectively. Distribution of pathological stage was pT1a in 582 patients (70.0%) and pT1b in 250 patients (30.0%).  During the observation period (median 44 months, range 3-114 months), postoperative disease recurrence developed in 38 patients (4.6%) and death occurred in 34 (4.1%). The 5-year recurrence-free and overall survival rates were 93.6% and 94.1%, respectively.  Of several factors examined, only age at diagnosis was identified as an independent predictor of both postoperative disease recurrence and overall survival in these patients. Furthermore, there were significant differences in the recurrence-free and overall survivals among patient groups stratified by age at diagnosis.

These findings suggest that age at diagnosis is a significant predictor of disease recurrence as well as overall survival in patients with pT1 RCC following surgical resection; therefore, intensive follow-up of older patients is necessary even for those with pT1 RCC.

Written by:
Sakai I, Miyake H, Muramaki M, Kondo Y, Kusuda Y, Yamada Y, Fujisawa M.   Are you the author?

Reference: BJU Int. 2011 Aug 19. Epub ahead of print.
doi: 10.1111/j.1464-410X.2011.10451.x

PubMed Abstract
PMID: 21854532

UroToday.com Renal Cancer Section