Preserving Renal Function without Compromising Oncological Outcomes: A Comparative Study of Partial and Total Nephrectomies in T3 Stage Renal Cell Carcinoma.

The utility of partial nephrectomy (PN) in locally advanced, stage T3 renal cell carcinoma (RCC) is controversial. This retrospective study aimed to review the oncological and functional outcomes of patients with T3a RCC who underwent PN. We included all patients with pT3a stage RCC undergoing either open, laparoscopic, or robotic PN at our center between January 2015 and 2023. A Wilcoxon rank sum test was utilized to compare nephrectomy types (radical nephrectomy [RN] vs PN). Survival analysis was conducted using Kaplan-Meier plots and a log-rank test. P-value < 0.05 indicated statistical significance. There were no significant differences in demographic characteristics between the RN and PN groups, except age (53.0 vs 6.5, respectively; P = 0.012) and body mass index (28.7 vs 34.3, respectively; P = 0.020). Furthermore, there were also no significant differences in the rates of local recurrence (P = 0.597), metastatic progression (P = 0.129), and chemotherapy use (P = 0.367) between nephrectomy types. Patient survival did not differ significantly based on the type of nephrectomy (log-rank P-value = 0.852). Together, our findings indicated that PN and RN yield near-equivalent oncological outcomes in terms of local recurrence, metastasis, and overall survival rates among pT3a RCC patients during a nearly 3-year follow-up period.

Journal of kidney cancer and VHL. 2023 Dec 26*** epublish ***

Ahmed Alasker, Turki Rashed Alnafisah, Mohammad Alghafees, Areez Shafqat, Belal Nedal Sabbah, Abdullah Alhaider, Abdulrahman Alsayyari, Naif Althonayan, Mohammed AlOtaibi, Salman Bin Ofisan, Mohammed Alghamdi, Nasser Albogami, Abdullah Al-Khayal

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Alfasial University, College of Medicine., Department of Urology, King Abdulaziz Medical City, Riyadh, Saudi Arabia., College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.