Cabozantinib Safety With Different Anticoagulants in Patients With Renal Cell Carcinoma.

In patients with renal cell carcinoma (RCC) on cabozantinib, venous thromboembolism (VTE) management remains challenging due to limited safety data regarding direct oral anticoagulants (DOACs) use in conjunction with cabozantinib. We investigated the safety of cabozantinib with different anticoagulants in patients with RCC.

In this retrospective multicenter study (9 sites), patients with advanced RCC were allocated into 4 groups: (1) cabozantinib without anticoagulation, cabozantinib with concomitant use of (2) DOACs, (3) low molecular weight heparin (LMWH), or (4) warfarin. The primary safety endpoint was the proportion of major bleeding events (defined per International Society on Thrombosis and Hemostasis criteria). The primary efficacy endpoint was the proportion of new/recurrent VTE while anticoagulated.

Between 2016 and 2020, 298 patients with RCC received cabozantinib (no anticoagulant = 178, LMWH = 41, DOAC = 64, and warfarin = 15). Most patients had clear cell histology (78.5%) and IMDC intermediate/poor disease (78.2%). Cabozantinib was first, second, or ≥ third line in 21.8%, 31.9%, 43.3% of patients, respectively. Overall, there was no difference in major bleeding events between the no anticoagulant, LMWH, and DOAC groups (P = .088). Rate of new/recurrent VTE was similar among anticoagulant groups. Patients with a VTE had a statistically significantly worse survival than without a VTE (HR 1.48 [CI 95% 1.05-2.08, P = .02]).

This real-world cohort provides first data on bleeding and thrombosis complications in patients with RCC treated with cabozantinib with or without concurrent anticoagulation. DOACs appear safe for VTE treatment for patients with RCC on cabozantinib, but optimized anticoagulation management, including individualized risk-benefit discussion, remains important in clinical practice.

Clinical genitourinary cancer. 2022 Nov 03 [Epub ahead of print]

Akram M Shayeb, Hannah Dzimitrowicz McManus, Danielle Urman, Chinmay Jani, Tian Zhang, Nazli Dizman, Luis Meza, Akhilesh Sivakumar, Chun L Gan, Pedro Barata, Mehmet A Bilen, Xin Gao, Daniel Heng, Sumanta Pal, Ravi Narra, Deepak Kilari, Marina D Kaymakcalan, Bradley McGregor, Toni K Choueiri, Rana R McKay

University of California San Diego, La Jolla, CA., Duke University, Durham, NC., Mount Auburn Hospital - Harvard Medical School, Cambridge, MA., Yale School of Medicine, CT., City of Hope, Duarte, CA., Emory University, Atlanta, GA., Tom Baker Cancer Center, Calgary, Alberta, Canada., University Hospitals Seidman Cancer Center, Cleveland, OH., Massachusetts General Hospital, Boston, MA., Medical College of Wisconsin, Milwaukee, WI., Dana Farber Cancer Institute, Boston, MA., University of California San Diego, La Jolla, CA. Electronic address: .