This study analyzed the ability of body composition to predict the outcome of patients with metastatic renal cell carcinoma (RCC) who received cytoreductive nephrectomy followed by systemic therapy.
A retrospective study was conducted from December 2010 to November 2017 in a single tertiary medical center. The medical charts and computed tomography images were reviewed. Statistical analysis included oncological features, their correlation with body composition factors, and overall survival.
Skeletal muscle volume was significantly higher in patients with Fuhrman grade 2 RCC than those with grade≥3. Patients with intermediate International Metastatic RCC Database Consortium risk had significantly higher BMI and skeletal muscle compared to those with poor risk. Multivariate analysis showed that increased skeletal muscle and decreased visceral adipose tissue were significant predictors of a better overall survival.
Body composition highly correlated with the oncological features of metastatic RCC and impacted survival.
Anticancer research. 2021 Oct [Epub]
I-Hung Shao, Ying-Hsu Chang, Ting-Wen Sheng, Chin-Chieh Tan, Li-Jen Wang, Cheng-Keng Chuang, Chun-Te Wu, See-Tong Pang
Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C., Department of Medicine, Chang Gung University, Taoyuan, Taiwan, R.O.C., Department of Medical Imaging and Intervention, New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital and Chang Gung University, New Taipei, Taiwan, R.O.C., Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan, R.O.C.; .