Environmental exposures related to parental habits in the perinatal period and the risk of Wilms' tumor in children.

Wilms' tumor is the most frequently diagnosed renal tumor in children. Little is known about its etiology. The aim of this study was to investigate the potential role of specific exposures related to parental habits such as parental smoking, maternal alcohol consumption and the use of household pesticides during pregnancy.

The ESTELLE study was a nationwide case-control study that included 117 Wilms' tumor cases and 1100 control children from the general French population, frequency-matched by age and gender. Unconditional logistic regression was used to estimate odds ratios and 95 % confidence intervals.

After controlling for matching variables and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with the risk of Wilms' tumor in children (OR 1.6 [95 % CI 1.1-2.3]). Insecticides were the most commonly reported type of pesticide and there was a positive association with their use (OR 1.7 [95 % CI 1.1-2.6]. The association was stronger when they were used more often than once a month (OR 1.9 [95 % CI 1.2-3.0]. Neither maternal smoking during pregnancy nor paternal smoking during preconception/pregnancy was associated with a risk of Wilms' tumor (ORs 1.1[95 % CI 0.7-1.8] and 1.1 [95 % CI 0.7-1.7], respectively). No association was observed with maternal alcohol intake during pregnancy (OR 1.2 [95 % CI 0.8-2.0]).

Our findings suggest an association between the maternal use of household pesticides during pregnancy and the risk of Wilms' tumor.

Cancer epidemiology. 2020 Apr 01 [Epub ahead of print]

Paula Rios, Hélène Bauer, Gudrun Schleiermacher, Claudia Pasqualini, Cécile Boulanger, Estelle Thebaud, Virginie Gandemer, Isabelle Pellier, Arnauld Verschuur, Hélène Sudour-Bonnange, Aurore Coulomb-l'Hermine, Alexandra Spiegel, Anne Notz-Carrere, Christophe Bergeron, Laurent Orsi, Brigitte Lacour, Jacqueline Clavel

CRESS, UMR1153, INSERM, Université de Paris, Villejuif, France. Electronic address: ., CRESS, UMR1153, INSERM, Université de Paris, Villejuif, France., Institut Curie, Paris, France., Gustave Roussy, Université Paris-Saclay, Child and Adolescent Oncology Department, Villejuif, France., CHU Toulouse, Hôpital Purpan, Toulouse, France., CHU de Nantes, Hôtel Dieu, Nantes, France., CHU Hôpital Sud, Université Rennes 1, Rennes, France., CHU d'Angers, Angers, France., AP-HM, Hôpital la Timone, Marseille, France., Centre Oscar Lambret, Lille, France., CHU Armand-Trousseau, Paris, France., CHU de Strasbourg, Hôpital Hautepierre, Strasbourg, France., CHU de Bordeaux, Hôpital Pellegrin, Bordeaux, France., IHOPe, Centre Léon Bérard, Lyon, France., CRESS, UMR1153, INSERM, Université de Paris, Villejuif, France; National Registry of Childhood Cancers, APHP, CHU Paul Brousse, Villejuif and CHU de Nancy, France.