Ninety percent of childhood renal tumors are Wilms tumors (nephroblastoma). While the Children's Oncology Group (COG) recommends primary surgery, the International Society of Paediatric Oncology (SIOP) recommends neoadjuvant chemotherapy, which can be initiated without histological confirmation if the presentation is typical for Wilms tumor. This review article describes the clinical, biological and radiologic criteria used by the SIOP community to consider diagnostic biopsy, i.e. when the renal origin is doubtful, when a pseudotumor is suspected or when a non-Wilms histology may be anticipated.
Pediatric radiology. 2020 Apr 05 [Epub ahead of print]
Hervé J Brisse, Yvan de la Monneraye, Liesbeth Cardoen, Gudrun Schleiermacher
Department of Imaging, Institut Curie, 26 rue d'Ulm, 75005, Paris, France. ., Oncology Center SIREDO (Care, innovation, research for cancer in children, adolescents and young adults), Institut Curie, Paris, France., Department of Imaging, Institut Curie, 26 rue d'Ulm, 75005, Paris, France., Paris Sciences et Lettres Research University, Paris, France.