Renal artery embolization is performed before radical nephrectomy (RN) for renal mass in order to induce preoperative infarction and to facilitate surgical intervention through decrease of intraoperative bleeding. Moreover, in metastatic renal cancer it seems to stimulate tumour-specific antibodies, even if no established benefits in clinical response or survival have been reported. The role of preoperative renal artery embolization (PRAE) in management of renal masses has been often debated and its real benefits are still unclear. Nevertheless, in huge and complex renal masses, which are often characterized by a high and anarchic blood supply and rapid local invasion, radical nephrectomy can be challenging even for skilled surgeons. The aim of this prospective randomized study was to evaluate the effectiveness and safety of PRAE in complex masses by comparing perioperative outcomes of RN with and without PRAE.
From December 2015 to May 2018 we enrolled prospectively 64 patients who underwent RN for localized (T2a-b) or locally advanced (T3 and T4) or advanced (N+, M+) renal cancers. Patients were divided in two groups. The first group included 30 patients who underwent PRAE; in the second group we enrolled 34 patients who did not undergo RN without PRAE. Perioperative outcomes in terms of operative time, blood loss, transfusion rate and length of hospitalization were evaluated. Statistical analysis was performed using GraphPad Prism 6.0 software.
Median blood loss was 250 ml (50-500) and 400 ml (50-1000) in the first and second group, respectively, with a statistically significant difference (p=0.0066). Median surgical time was 200 min (90-390) and 240 min (130-390) in PRAE and No-PRAE group (p=0.06), respectively. No major complications occurred after embolization. Overall complication rate in Group 1 and 2 was 46.7% (14/30) and 50% (17/34), respectively (p=0.34). No major complications occurred in both groups. The mean follow up was 21,5 months.
Our results prove PRAE to be a safe procedure with low complications rate. To our experience, PRAE seems to be a useful tool in surgical management of a large mass and advanced disease.
Open medicine (Warsaw, Poland). 2019 Nov 07*** epublish ***
Giovanni Cochetti, Michele Del Zingaro, Andrea Boni, Massimiliano Allegritti, Jacopo Adolfo Rossi de Vermandois, Alessio Paladini, Maria Giulia Egidi, Giulia Poli, Pietro Ursi, Roberto Cirocchi, Ettore Mearini
Department of Surgical and Biomedical Sciences, Urology Clinic of Perugia, Perugia University, P.le Menghini, 06100, Perugia, Italy., Division of Interventional Radiology, S. Maria Hospital, Terni, Italy., Department of General Surgery Paride Stefanini, Umberto I Policlinico Roma, Italy., Department of Surgical and Biomedical Sciences, Division of Week surgery, S. Maria Hospital, Terni, Italy.