METHODS: Patients with solid tumors were enrolled in an ongoing Phase I study. Safety (including daily BP monitoring), single- and multiple-dose PK, biomarkers, and clinical activity were evaluated. The response was assessed by RECIST.
RESULTS: 43 patients were enrolled in the dose escalation phase at doses ranging from 50 mg 3 times weekly to 2000 mg daily (qd) in 11 cohorts. Mean half-life was ∼ 35 hrs. Accumulation of 1.5 - 3 fold and Cmax/Cmin of ∼ 2 were observed at steady-state. Maximal exposure with trough concentrations (C24) > 18 μg/mL were observed after doses ≥ 800 mg qd. MTD was not achieved. The most frequent drug-related AEs were NCI CTC2, Gr 1 and 2: nausea (Gr 1/2 n=15, Gr 3 n=1), diarrhea (Gr 1/2 n=15), fatigue (Gr 1/2 n=12, Gr 3 n=1), HTN (Gr 1/2 n=6, Gr 3 n=6), anorexia (Gr 1/2 n=12), and vomiting (Gr 1/2 n=9, Gr 3 n=1). Hair depigmentation was observed (n=6/14) at doses of ≥ 800 mg. The greatest magnitude in BP change was observed at 800 mg and correlated with C24 of > 20 μg/mL. HTN was amenable to treatment and was reversible upon cessation of GW786034. No patients were withdrawn from study solely due to HTN. One of 3 patients treated at 2000 mg qd developed Gr 3 fatigue (DLT). Tumor shrinkage (minimal response) was observed in all 3 patients with renal cell cancer treated at ≥ 800 mg qd and in one pt with Hurthel cell tumor. Six additional patients (melanoma n=1, sarcoma n=3, lung n=1, neuroendocrine n=1) remained on study for ≥ 6 mos with SD.
CONCLUSION: GW786034 was generally well tolerated with preliminary evidence of anti-tumor activity in cancer patients. HTN and hair depigmentation were indicative of VEGFR and c-kit modulation. Two dose cohorts (800 mg qd and 300 mg bid) are being expanded.
H. Hurwitz, A. Dowlati, S. Savage, N. Fernando, S. Lasalvia, B. Whitehead, B. Suttle, D. Collins, P. Ho, L. Pandite
Duke University, Durham, North Carolina; Case Western Reserve, Cleveland, Ohio; GlaxoSmithKline, Durham, North Carolina
Journal of Clinical Oncology 2005 23:16_suppl, 3012-3012, Published online December 12, 2016. DOI: 10.1200/jco.2005.23.16_suppl.3012