Gender- and cholesterol-specific predictive value of body mass index in renal cell carcinoma: A multicenter study

Recently, there have been some reports on preoperative body mass index (BMI) and total cholesterol (TC) as a prognostic predictor for patients with renal cell carcinoma (RCC) but the topic is controversial and still poorly understood. So we analyzed the effects of BMI and TC on the prognosis of RCC.

Retrospective data from 1988 to 2015 were collected from eight centers with a total of 7,271 patients surgically treated for nonmetastatic RCC. Receiver operating characteristic curve analysis was analyzed and the highest Youden index was shown at 163.5 mg/dL. According to the Asian BMI criteria, patients were divided into normal BMI < 25 kg/m2 and high BMI ≥ 25 kg/m2 . Kaplan-Meier analysis, multivariate Cox regression model were performed to identify the overall survival (OS) and the recurrence-free survival (RFS).

Normal BMI and low TC group was associated with the shortest OS and RFS as compared to the other groups significantly. In the male patients, the results showed similar to the whole sample. But in the female, BMI had no effect on both OS and RFS. On multivariate Cox regression analysis, low TC was an independent predictor for OS in both genders. However, normal BMI was a significant prognostic factor in the males only.

Preoperative BMI and TC are good predictive factors for both OS and RFS significantly in RCC patients. Also, TC was an independent predictor for OS in all RCC patients; however, BMI was a significant predictor in males only.

Asia-Pacific journal of clinical oncology. 2018 Oct 10 [Epub ahead of print]

Hyun Cheol Jeong, Fahad K Bashraheel, Seok-Soo Byun, Cheol Kwak, Eu Chang Hwang, Seok Ho Kang, Jinsoo Chung, Tae-Hwan Kim, Yong-June Kim, Sung-Hoo Hong

Department of Urology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea., Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea., Department of Urology, College of Medicine, Seoul National University, Seoul, Korea., Department of Urology, College of Medicine, Chonnam National University, Gwangju, Korea., Department of Urology, College of Medicine, Korea University, Seoul, Korea., Department of Urology, National Cancer Center, Goyang, Korea., Department of Urology, College of Medicine, Kyungpook National University, Daegu, Korea., Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Korea.

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe