Results on the association of Vitamin D receptor (VDR) gene polymorphism with renal cell carcinoma (RCC) susceptibility from the present reports are still debating. This meta-analysis was conducted to assess the association of VDR ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and Fok1 (rs2228570) gene polymorphisms with RCC risk.
The association studies were recruited from PubMed on May 1, 2016, and eligible reports were extracted and data were synthesized using meta-analysis method.
Six investigations were included into this meta-analysis for the relationship between VDR gene polymorphism and RCC susceptibility. In this meta-analysis, the ApaI A allele, AA genotype, aa genotype, and Fok1 FF genotype were associated with RCC susceptibility in Asians. However, VDR BsmI and TaqI gene polymorphisms were not associated with the RCC risk in Asians, Caucasians, and overall populations. Furthermore, Fok1 gene polymorphism was not associated with the RCC risk in Caucasians and overall populations.
ApaI gene polymorphism and Fok1 FF genotype were associated with RCC susceptibility in Asians.
Journal of cancer research and therapeutics. 2018 Jan [Epub]
Zhi-Jun Lin, Xia-Lan Zhang, Zhen-Sheng Yang, Xiao-Yu She, Yi Xie, Wei-Ji Xie
Department of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China., Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.