Denosumab for the treatment of bone disease in solid tumors and multiple myeloma

Bone is a common site for malignant involvement, either as a site of metastasis, especially in breast or prostate cancer, or as a defining characteristic of the disease, as in multiple myeloma. Bone disease is a major source of morbidity, and half of patients with bone involvement develop skeletal-related events such as pathological fractures or cord compression requiring surgery and/or radiation. Skeletal involvement also increases mortality, as pathologic fractures increase the risk of dying by 20-40%. Osteoclast inhibition with bisphosphonates such as zoledronic acid and recently denosumab has been a significant improvement for bone disease. This review will focus on denosumab in the treatment of bone metastases and highlight the recent findings in multiple myeloma.

Future oncology (London, England). 2017 Oct 20 [Epub ahead of print]

Andrew J Yee, Noopur S Raje

Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.