Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy

In this issue of Cancer Cell, Bluemn et al. report that ∼20% of metastatic castration-resistant prostate cancers express neither AR nor neuroendocrine genes and show AR pathway-independent growth, driven instead by a FGFR/MAPK/ID1 signaling cascade. These results provide a strong rationale for co-targeting AR bypass pathways with initial AR antagonism.

Cancer cell. 2017 Oct 09 [Epub]

W Nathaniel Brennen, John T Isaacs

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center (SKCCC), The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center (SKCCC), The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: .