11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.

patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.

twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).

SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

Cancer investigation. 2017 Oct 05 [Epub ahead of print]

Ciro Franzese, Egesta Lopci, Lucia Di Brina, Giuseppe Roberto D'Agostino, Pierina Navarria, Pietro Mancosu, Stefano Tomatis, Arturo Chiti, Marta Scorsetti

a Radiotherapy and Radiosurgery , Humanitas Clinical and Research Center , Via Manzoni Rozzano ( Milano ) - Italy., b Nuclear Medicine , Humanitas Clinical and Research Center , Via Manzoni Rozzano ( Milano ) - Italy.

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