Understanding urinary toxicity after radiotherapy for prostate cancer: first steps forward.

One of the most relevant achievements of Professor Gianni Bonadonna was the implementation of the methodology of controlled clinical trials in medical oncology. It is valid for all cancer types, oncological disciplines and clinical endpoints, both survival and toxicity. This narrative review reports on the status of the current knowledge of the radiation-induced urinary syndrome after external-beam radiotherapy for prostate cancer. In recent years, the syndrome has been the object of large-scale prospective observational trials specifically devoted to investigating the association of patient and treatment features with acute/late urinary toxicity. The first results of these trials allow initial attempts at predictive modeling, which can serve as a basis for the optimization of patient selection and treatment planning.

Tumori. 2017 Sep 07 [Epub ahead of print]

Tiziana Rancati, Federica Palorini, Cesare Cozzarini, Claudio Fiorino, Riccardo Valdagni

Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy., Department of Radiation Oncology, San Raffaele Scientific Institute, Milan - Italy., Department of Medical Physics, San Raffaele Scientific Institute, Milan - Italy.