Disentangling PTEN-cooperating tumor suppressor gene networks in cancer

We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer.

Molecular & cellular oncology. 2017 May 04*** epublish ***

Jorge de la Rosa, Julia Weber, Roland Rad, Allan Bradley, Juan Cadiñanos

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK., Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany.