Incidence of prostate cancer is rising worldwide. Multiple factors have been suggested for the aetiology of prostate cancer including ethnic, genetic and diet. Vitamin D (calcitriol) has been shown to have role in cell growth and differentiation and its deficiency is implicated as one of the aetiological factors in prostate cancer. Prostatic epithelial cells express Vitamin D Receptor (VDR) as well as 1α- hydroxylase enzyme that are required for the synthesis of calcitriol and its action. Polymorphism in VDR gene has been associated with prostate cancer in some epidemiological studies; but, there is paucity of information in the Indian context.
The present study was aimed to explore the association of VDR gene polymorphism with the development of prostate cancer.
Three Single Nucleotide Polymorphisms (SNP) sites viz., FokI, TaqI and ApaI were analysed in 120 cases of prostate cancer which were compared with their 120 healthy first degree relatives and 120 non-related controls in the Department of Biochemistry in collaboration with the Department of Urology.
Analysis showed significantly decreased incidence of Tt and Aa genotype in prostate cancer patients as compared to healthy non-relative controls (p=0.016 and 0.043 respectively). As compared to first degree relatives, incidence of Tt genotype is significantly lower in cases (p=0.005). No significant association was found with FokI polymorphism.
This study suggests the protective role of heterozygous genotypes of TaqI and ApaI polymorphism against the development of prostate cancer.
Journal of clinical and diagnostic research : JCDR. 2017 Jun 01 [Epub]
Pankaj Ramrao Kambale, Deepa Haldar, B C Kabi, Kalpana Pankaj Kambale
Assistant Professor, Department of Biochemistry, S.M.B.T. Institute of Medical Sciences and Research Centre, Nashik, Maharashtra, India., Senior Resident, Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India., Professor Director, Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India., Senior Lecturer, Department of Periodontology, S.M.B.T. Institute of Dental Sciences and Research, Nasik, Maharashtra, India.