Cancer incidence in the AGRICAN cohort study (2005-2011)

Numerous studies have been conducted among farmers, but very few of them have involved large prospective cohorts, and few have included a significant proportion of women and farm workers. Our aim was to compare cancer incidence in the cohort (overall, by sex, and by work on farm, occupational status and pesticide use) within the general population.

More than 180,000 participants in the AGRICAN cohort were matched to cancer registries to identify cancer cases diagnosed from enrolment (2005-2007) to 31st December 2011. We calculated standardized incidence ratios (SIRs) and 95% confidence intervals (95%CIs).

Over the period, 11,067 incident cancer cases were identified (7304 men and 3763 women). Overall cancer incidence did not differ between the cohort and the general population. Moreover, SIRs were significantly higher for prostate cancer (SIR=1.07, 95%CI 1.03-1.11) and non-Hodgkin lymphoma (SIR=1.09, 95%CI 1.01-1.18) among men, skin melanoma among women (SIR=1.23, 95%CI 1.05-1.43) and multiple myeloma (men: SIR=1.38, 95%CI 1.18-1.62; women: SIR=1.26, 95%CI 1.02-1.54). In contrast, SIRs were lower for upper aerodigestive tract and respiratory cancers. Increase in risk was greater in male farm workers for prostate and lip cancer, in female farm workers for skin melanoma, and in male farm owners for multiple myeloma. Moreover, incidence of multiple myeloma and skin melanoma was higher among male and female pesticide users respectively.

We found a decreased incidence for tobacco-related cancers and an increased incidence of prostate cancers, skin melanoma and multiple myeloma. Specific subgroups had a higher cancer incidence related to occupational status and pesticide use.

Cancer epidemiology. 2017 Jul 11 [Epub ahead of print]

Clémentine Lemarchand, Séverine Tual, Noémie Levêque-Morlais, Stéphanie Perrier, Aurélien Belot, Michel Velten, Anne-Valérie Guizard, Elisabeth Marcotullio, Alain Monnereau, Bénédicte Clin, Isabelle Baldi, Pierre Lebailly, AGRICAN group

INSERM, UMR 1086 Cancers et Préventions, F-14076, Caen, France; Université de Caen Normandie, F-14032, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, F-14076, Caen, France. Electronic address: ., INSERM, UMR 1086 Cancers et Préventions, F-14076, Caen, France; Université de Caen Normandie, F-14032, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, F-14076, Caen, France., Hospices Civils de Lyon, Service de Biostatistique, F-69003, Lyon, France., Registre des Cancers du Bas-Rhin, Faculté de Médecine, Université de Strasbourg, F-67085, Strasbourg, France., INSERM, UMR 1086 Cancers et Préventions, F-14076, Caen, France; Registre Général des Tumeurs du Calvados, Centre François Baclesse, F-14076, Caen, France., Caisse Centrale de la Mutualité Sociale Agricole, Direction de la santé sécurité au travail, F-93547, Bagnolet, France., Registre des hémopathies malignes de la Gironde, F-33076, Bordeaux, France; INSERM, ISPED, Centre INSERM U1219-Bordeaux Population Health Center, EPICENE team, F-33076, Bordeaux, France; Université de Bordeaux, ISPED, Centre INSERM U1219-Bordeaux Population Health Center, EPICENE Team, F-33000, Bordeaux, France., INSERM, UMR 1086 Cancers et Préventions, F-14076, Caen, France; Université de Caen Normandie, F-14032, Caen, France; CHU de Caen, Service de Pathologie Professionnelle, F-14033, Caen, France., INSERM, ISPED, Centre INSERM U1219-Bordeaux Population Health Center, EPICENE team, F-33076, Bordeaux, France; Service de Médecine du Travail et Pathologies professionnelles, CHU de Bordeaux, F-33000, Bordeaux, France; Université de Bordeaux, ISPED, Centre INSERM U1219-Bordeaux Population Health Center, EPICENE Team, F-33000, Bordeaux, France.