Prostate cancer, one of the most common malignant tumors among men, is closely associated with obesity and, thus far, several studies have suggested the association between obesity and aggressive pathological characteristics in the United States. However, the effect of obesity on prostate cancer mortality is controversial, and it remains unclear whether obesity contributes to the aggressiveness of prostate cancer in Asian patients. The aim of the present study was to investigate the association between body mass index (BMI) and the clinicopathological characteristics of prostate cancer in 2,003 Japanese patients who underwent radical prostatectomy. There was a significant association between higher BMI and higher Gleason score (GS). The multivariate analysis also revealed that BMI was an independent indicator for GS ≥8 at surgery. Moreover, among patients with lower prostate-specific antigen levels, biochemical recurrence-free survival was significantly worse in those with higher BMI. These results suggest that BMI may be a classifier for predicting adverse pathological findings and biochemical recurrence after radical prostatectomy in Japanese patients.
Molecular and clinical oncology. 2017 Apr 10 [Epub]
Keisuke Goto, Hirotaka Nagamatsu, Jun Teishima, Yuki Kohada, Shinsuke Fujii, Yoshimasa Kurimura, Koji Mita, Masanobu Shigeta, Satoshi Maruyama, Yoji Inoue, Mitsuru Nakahara, Akio Matsubara
Department of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734-8551, Japan., Department of Urology, Hiroshima City Asa Hospital, Hiroshima 731-0293, Japan., Department of Urology, Kure Medical Center, Chugoku Cancer Center, Kure, Hiroshima 737-0023, Japan., Department of Urology, Hiroshima General Hospital, Hatsukaichi, Hiroshima 738-8503, Japan., Department of Urology, Mazda Hospital, Fuchu, Hiroshima 735-8585, Japan., Department of Urology, Hiroshima Prefectural Hospital, Hiroshima 734-8530, Japan.