We studied the profile of miRNA secreted into culture medium by DU145 prostate cancer cells and identified a subset of miRNAs characterized by the absence of correlation of their content in the cell and medium, which is likely a result of specific secretion. Three of these miRNA, hsa-miR-4417, hsa-miR-3175, and hsa-miR-6782-5p, exhibit the highest expression and are candidate circulating biomarkers for metastatic activity of prostate cancer. Two of these miRNA are coded by introns of genes linked with genome stability maintenance and chromatin remodeling regulation.
Bulletin of experimental biology and medicine. 2017 Apr 21 [Epub ahead of print]
K A Fomicheva, A I Osip'yants, E N Knyazev, T R Samatov, M Yu Shkurnikov
Р. A. Hertsen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre, The Ministry of Health of the Russian Federation, Moscow, Russia., BioClinicum Center, Moscow, Russia.