Is BMI the Best Adiposity Measure for Prostate Cancer Risk? Results From a VA Biopsy Cohort

To test multiple adiposity measures and prostate cancer (PC) risk in men undergoing prostate biopsy. We hypothesized that BMI, body fat and waist circumference would be highly correlated and all would be associated with aggressive PC, but not overall risk.

A case (483) -control (496) study among men undergoing prostate biopsy from 2007-2016 was conducted at the Durham Veterans Affairs Medical Center. Anthropometric measurements and self-reported were taken. Percent body fat was measured. Associations between adiposity measures and PC risk and high-grade PC (Gleason ≥7) were examined using logistic regression.

BMI, percent body fat, and waist circumference were highly correlated (ρ ≥0.79) (p<0.001). On multivariable analysis, BMI (p=0.011) was associated with overall PC risk, but percent body fat (p=0.16) and waist circumference (p=0.19) were not. However, all adiposity measurements were associated with high-grade disease (p<0.001). We found a strong relationship between self-reported and measured weight (ρ=0.97) and height (ρ=0.92).

BMI, body fat and waist circumference were all highly correlated and associated with aggressive PC. This study supports the idea that higher adiposity is selectively associated with high-grade PC and reinforces the continued use of self-reported BMI as a measure of obesity in epidemiological studies of PC.

Urology. 2017 Apr 10 [Epub ahead of print]

Lourdes Guerrios-Rivera, Lauren Howard, Jennifer Frank, Amanda De Hoedt, Devon Beverly, Delores J Grant, Cathrine Hoyo, Stephen J Freedland

Urology Section, Surgery Department, Veterans Administration Caribbean Healthcare System San Juan, University of Puerto Rico Medical Sciences Campus, Puerto Rico., Department of Biostatistics and Bioinformatics, Duke University School of Medicine; Urology Section, Veterans Affairs Medical Center Durham, Durham, North Carolina., Urology Section, Veterans Affairs Medical Center Durham, Durham, North Carolina., Department of Biology and Cancer Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University., Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State., Urology Section, Veterans Affairs Medical Center Durham, Durham, North Carolina; Division of Urology, Department of Surgery, and the Samuel Oschin Comprehensive Cancer Center, Cedars Sinai Medical Center. Electronic address: .

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