Adherence to nutrition-based cancer prevention guidelines and breast, prostate and colorectal cancer risk in the MCC-Spain case-control study

Prostate, breast and colorectal cancer are the most common tumours in Spain. The aim of the present study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and prostate, breast and colorectal cancer, in the MCC-Spain case-control study. A total of 1718 colorectal, 1343 breast and 864 prostate cancer cases and 3431 population-based controls recruited between 2007 and 2012, were included in the present study. The World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) score based on six recommendations for cancer prevention (on body fatness, physical activity, foods and drinks that promote weight gain, plant foods, animal foods and alcoholic drinks; score range 0-6) was constructed. We used unconditional logistic regression analysis adjusting for potential confounders. One-point increment in the WCRF/AICR score was associated with 25% (95% CI 19%; 30%) lower risk of colorectal, and 15% (7%; 22%) lower risk of breast cancer; no association with prostate cancer was detected, except for cases with a Gleason Score ≥ 7 (poorly differentiated/undifferentiated tumours) (OR 0.87, 95% CI 0.76; 0.99). These results add to the wealth of evidence indicating that a great proportion of common cancer cases could be avoided by adopting healthy lifestyle habits. This article is protected by copyright. All rights reserved.

International journal of cancer. 2017 Apr 05 [Epub ahead of print]

Dora Romaguera, Esther Gracia-Lavedan, Amaia Molinuevo, Jordi de Batlle, Michelle Mendez, Victor Moreno, Carmen Vidal, Adela Castelló, Beatriz Pérez-Gómez, Vicente Martín, Antonio J Molina, Verónica Dávila-Batista, Trinidad Dierssen-Sotos, Inés Gómez-Acebo, Javier Llorca, Marcela Guevara, Jesús Castilla, Carmen Urtiaga, Cristóbal Llorens-Ivorra, Guillermo Fernández-Tardón, Adonina Tardón, José Andrés Lorca, Rafael Marcos-Gragera, José María Huerta, Rocío Olmedo-Requena, José Juan Jimenez-Moleon, Jone Altzibar, Silvia de Sanjosé, Marina Pollán, Núria Aragonés, Gemma Castaño-Vinyals, Manolis Kogevinas, Pilar Amiano

ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain., CIBER Epidemiology and Public Health (CIBER-ESP), Health Research Institute Carlos III, 28029, Madrid, Spain., Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova, IRBLleida, Lleida, Spain., Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Research Group on Gene-Environment Interactions and Health. University of León, León, Spain., Health Department, Public Health Division of Gipuzkoa, Basque Region, Spain., Centro de Salud Pública de Dénia. Consellería de Sanidad Universal y Salud Pública. Generalitat Valenciana. Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Valencia, Spain., Centro de Investigación en Salud y Medio Ambiente (CYSMA). Universidad de Huelva, Huelva, Spain., Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan Department of Health Government of Catalonia, Catalan Institute of Oncology, Girona, Spain., Breast Cancer Detection Programme. Osakidetza-Health Basque Service.