[Role of angiotensin II receptor type 2 in predicting biochemical recurrence in the treatment of prostate cancer]

To identify markers for predicting aggressive forms of prostate cancer.

The study retrospectively evaluated expression of angiotensin II type 2 receptors (AT2-R) in prostate needle biopsy tissue from patients with and without biochemical recurrence after combined hormone and radiation therapy.

The study findings showed that low expression of AT2-R in prostate tissue was associated with a high risk of biochemical recurrence. The data on the nature of AT2-R expression in prostate tissue of prostate cancer patients may be considered as a tool for predicting biochemical recurrence after combined hormone and radiation therapy. The test has a sensitivity of 87.5% and specificity of 85.71%.

Urologiia (Moscow, Russia : 1999). 2016 Dec [Epub]

M B Chibichyan, M I Kogan, E A Chernogubova, I A Pavlenko, D G Matishov

Institute of Arid Zones of Southern Scientific Center of RAS, Rostov-on-Don., Rostov Region Pathology and Autopsy Bureau, Rostov-on-Don.