Focal Signet Ring Cell High-Grade Prostatic Intraepithelial Neoplasia on Needle Biopsy

Signet ring cell prostatic intraepithelial neoplasia is a rare speculated variant of high-grade prostatic intraepithelial neoplasia (HGPIN). Here, we present a free-standing and isolated signet ring cell HGPIN that was not associated with invasive carcinoma on needle biopsy and demonstrated the existence of this type of HGPIN variant. The differentiation between HGPIN and intraductal carcinoma of prostate is also discussed.

International journal of surgical pathology. 2016 Dec 01 [Epub ahead of print]

Guang-Qian Xiao, Pamela D Unger

1 Keck Medical Center of the University of Southern California, Los Angeles, CA, USA., 2 Lenox Hill Hospital-Northwell Health, New York, NY, USA.