An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is because of WTC-related exposures or enhanced surveillance. Prostate cancer cases (2002-2013) were obtained from the WTC Health Program. Age, race, and Gleason score distribution were compared with New York State Cancer Registry cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also carried out, adjusting for age, race, and WTC exposure categories. WTC respondents had a prostate cancer age-standardized rate ratio of 1.65 [95% confidence interval (CI): 1.37-1.93] compared with New York State; age-specific ratios were highest for ages 30-49 (2.28; 95% CI: 1.51-3.43), 70-74 (2.05; 95% CI: 1.03-4.10), and 80-84 years (5.65; 95% CI: 1.41-22.58). High WTC exposure was associated with advanced clinical stage (5.58; 95% CI: 1.05-29.76; Ptrend=0.03). WTC respondents continue to have a higher prostate cancer rate compared with New York State as a whole. Respondents with a higher WTC exposure level may have had more advanced clinical stage of prostate cancer.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2016 Jan 24 [Epub ahead of print]
Dana Hashim, Paolo Boffetta, Matthew Galsky, William Oh, Roberto Lucchini, Michael Crane, Benjamin Luft, Jaqueline Moline, Iris Udasin, Denise Harrison, Emanuela Taioli
aDepartment of Preventive Medicine bTisch Cancer Institute cDivision of Hematology and Medical Oncology dInstitute for Translational Epidemiology eDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai fDepartment of Medicine, New York University School of Medicine, Bellevue Hospital Center, New York gDepartment of Medicine, State University of New York at Stony Brook, Stony Brook hDepartment of Occupational Medicine, Epidemiology and Prevention, Hofstra North Shore-LIJ School of Medicine, Great Neck, New York iDepartment of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA jDivision of Occupational Medicine, University of Brescia, Brescia, Italy.