Urethral strictures after radiation therapy for prostate cancer

Urethral stricture after radiation therapy for localized prostate cancer is a delicate problem as the decreased availability of tissue healing and the close relation to the sphincter complicates any surgical approach. We here review the pathophysiology, dosimetry, and the disease specific aspects of urethral strictures after radiotherapy. Moreover we discuss different treatment option such as direct vision internal urethrotomy as well as techniques for open reconstruction with and without tissue transfer.

Investigative and clinical urology. 2016 Sep 07 [Epub]

Felix Moltzahn, Alan Dal Pra, Marc Furrer, George Thalmann, Martin Spahn

Department of Urology, Inselspital Bern, Bern, Switzerland., Department of Radiation-Oncology, Inselspital Bern, Bern, Switzerland.