Association between lifetime alcohol consumption and prostate cancer risk: A case-control study in Montreal, Canada

Alcohol intake may increase the risk of prostate cancer (PCa). Many previous studies harbored important methodological limitations.

We conducted a population-based case-control study of PCa comprising 1933 cases and 1994 controls in Montreal, Canada. Lifetime alcohol consumption was elicited, by type of beverage, during in-person interviews. Odds ratios (OR) and 95% confidence intervals (CI) assessed the association between alcohol intake and PCa risk, adjusting for potential confounders and considering the subjects' PCa screening history.

We observed a weak, non-significant positive association between high consumption of total alcohol over the lifetime and risk of high-grade PCa (OR=1.18, 95% CI 0.81-1.73). Risk estimates were more pronounced among current drinkers (OR=1.40, 95%CI 1.00-1.97), particularly after adjusting for the timing of last PCa screening (OR=1.52, 95%CI 1.07-2.16). These associations were largely driven by beer consumption. The OR for high-grade PCa associated with high beer intake was 1.37 (95%CI 1.00-1.89); it was 1.49 (95%CI 0.99-2.23) among current drinkers and 1.68 (95% CI 1.10-2.57) after adjusting for screening recency. High cumulative consumption of spirits was associated with a lower risk of low-grade PCa (OR=0.75, 95%CI 0.60-0.94) but the risk estimate no longer achieved statistical significance when restricting to current users. No association was found for wine consumption.

Findings add to the accumulating evidence that high alcohol consumption increases the risk of high-grade PCa. This association largely reflected beer intake in our population, and was strengthened when taking into account PCa screening history.

Cancer epidemiology. 2016 Sep 21 [Epub ahead of print]

Claire Demoury, Pierre Karakiewicz, Marie-Elise Parent

Epidemiology and Biostatistics Unit, INRS-Institut Armand-Frappier, Institut national de la recherche scientifique, University of Québec, 531 boul. des Prairies, Laval, QC, H7V 1B7, Canada. Electronic address: ., Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, 1058 Saint-Denis, Montréal, Québec, H2X 3J4, Canada; Department of Urology, University of Montreal Health Center, 264 René-Lévesque Est, room 500, Montréal, Québec, H2X 1P1, Canada. Electronic address: ., Epidemiology and Biostatistics Unit, INRS-Institut Armand-Frappier, Institut national de la recherche scientifique, University of Québec, 531 boul. des Prairies, Laval, QC, H7V 1B7, Canada; School of Public Health, Department of Social and Preventive Medicine, University of Montreal, 7101 avenue du Parc, 3rd floor, Montréal, Québec, H3N 1X9, Canada; University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Tour Viger, Pavillon R, Montréal, Québec, H2X 0A9, Canada. Electronic address: .