Taxane acute pain syndrome (TAPS) is characterized by myalgia and arthralgia starting 24 to 48 hours after taxane-based chemotherapy and lasting ≤ 7 days. Little is known about its incidence and predisposing factors in patients with prostate cancer. A systematic review was performed to identify studies reporting the incidence and risk factors for TAPS in patients receiving taxane-based chemotherapy for prostate cancer. Embase, Ovid Medline, and other nonindexed citations were searched from 1947 to July 7, 2015. Randomized trials and prospective observational studies reporting the outcomes for prostate cancer patients who had received taxane-based chemotherapy were assessed. Four reviewers independently screened the citations and full text reports for data collection. Of 980 citations, 5 studies (2710 patients) met the eligibility criteria. The incidence of myalgia and arthralgia was reported in 4 trials (14%, [29% and 38%], 44.2%, and 46%). TAPS was not reported with cabazitaxel chemotherapy. Clinical risk factors were identified in 4 studies, suggesting that TAPS was numerically more common in the castrate-resistant setting and when concurrent medications (eg, corticosteroids) were not used. Although the TAPS incidence has been poorly reported in clinical practice, the results of the present study suggest that arthralgia and myalgia are a common toxicity in patients with prostate cancer. An improved and universal definition of TAPS, patient-directed reporting of TAPS, and improved standardized assessments are needed to better identify patients at the greatest risk of experiencing TAPS and improving patient care.
Clinical genitourinary cancer. 2016 Jul 28 [Epub ahead of print]
Ricardo Fernandes, Sasha Mazzarello, Brian Hutton, Risa Shorr, Mohammed F K Ibrahim, Carmel Jacobs, Michael Ong, Mark Clemons
Division of Medical Oncology, Department of Medicine, The Ottawa Hospital Cancer Centre and University of Ottawa, Ottawa, Ontario, Canada., Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada., Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of Ottawa School of Epidemiology, Public Health and Preventative Medicine, Ottawa, Ontario, Canada., The Ottawa Hospital, Ottawa, Ontario, Canada., Division of Medical Oncology, Department of Medicine, The Ottawa Hospital Cancer Centre and University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada. Electronic address: .