Deciphering the Effect of Metformin on Prostate Cancer Risk by Ethnicity.

Previous studies on the relationship between metformin therapy and prostate cancer risk have yielded conflicting results. Cancer researchers are not sure how to explain these findings. In recent years, new evidence suggested that the effect of metformin on prostate cancer risk might vary in different ethnicities. As we enter the era of precision medicine, to clarify the effect of metformin on cancer risk, race-specific molecular factors should be considered and incorporated into future prostate cancer studies.

Cancer prevention research (Philadelphia, Pa.). 2016 Jul 18 [Epub ahead of print]

Edward Uchio, Frank L Meyskens, Ping H Wang

Urology, University of California, Irvine., Chao Family Comprehensive Cancer Center, University of California Irvine., Medicine, University of California, Irvine .