Evaluation of survivin expression in prostate specimens of patients with prostate adenocarcinoma and benign prostate hyperplasia underwent transurethral resection of the prostate or prostatectomy.

Survivin is a newly found member of the inhibitors of apoptosis proteins, which plays a certain role in cancer. Survivin has a distinctly different expression in cancers, including prostate cancer. We are searching for the relationship between survivin levels in normal prostate tissue, benign prostate hyperplasia (BPH), and prostate adenocarcinoma in this study.

The study surveyed 282 prostate samples, 94 normal, 94 BPH, and 94 prostate adenocarcinoma samples. Survivin expression was absent in normal prostate tissues. In the BPH group, the survivin expression level was higher than that of the normal group. In the adenocarcinoma group, the survivin expression level was higher than that of the BPH group. There was a significant association between survivin expression level and the adenocarcinoma stage.

Although there is no expression of survivin in normal prostate tissue, its expression is slightly positive in BPH. High survivin expression is related to a higher Gleason score in the adenocarcinoma of the prostate.

SpringerPlus. 2016 May 14*** epublish ***

Mansooreh Eslami, Tahere Khamechian, Tahere Mazoochi, Hasan Ehteram, Mojtaba Sehat, Javad Alizargar

Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran., Anatomical Science Research Center, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran., Gametogenese Research Center, Kashan University of Medical Sciences, 5th Km Qotbe Ravandi Blv, Kashan, Islamic Republic of Iran., Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran., Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran., Student Research Committee, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.