Currently, there are high dose rate afterloaders available that can drive two different radioactive sources simultaneously. The source-source and source-cable attenuations are not taken into account by current planning systems. The purpose of this work is to characterize these effects and their overall impact on clinically relevant metrics.
FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
A (192)Ir ((169)Yb) Flexitron source is modeled within a Monte Carlo code, and its water dose distribution is evaluated. A second source (cable) is placed parallel at various distances to quantify the dose perturbations. The dual-source setup is then transposed to clinical prostate plans (n = 11). Each plan D90 is compared to the single-source D90. The worst-case scenario (two sources traveling in closely located positions) establishes the upper bounds of the deviations. Two setups are considered with sources constrained in catheter pairs or freely distributed. A metric proportional to the dwell times and R(-2) (where R is the intersource separation) helps determine the source position in each configuration.
The dose profiles vs. R(-2) (3-20 mm) show a maximal dose reduction effect of 65% (25%) for (169)Yb ((192)Ir) at small distances. A shadow region with at least 10% dose difference extends up to 10 cm. A similar study with a steel drive cable shows similar behavior with a maximal decrease of 10% (3%) under irradiation of a (169)Yb ((192)Ir) source. The relative D90 difference with the single source setup is 2.3% on average, up to 3.7%. It is obtained by superimposing the contributions from catheter pairs in the dual-source loading.
Overall deviations observed in D90 compared to a single source setup are not significant for all cases studied.
Brachytherapy. 0000 [Epub]
Charles-Antoine Collins-Fekete, Mathieu Plamondon, Frank Verhaegen, Luc Beaulieu
Département de physique, de génie physique et d'optique et Centre de recherche sur le cancer, Université Laval, Québec, Canada; Département de radio-oncologie et CRCHU de Québec, CHU de Québec, Québec, Canada., Département de physique, de génie physique et d'optique et Centre de recherche sur le cancer, Université Laval, Québec, Canada., Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands; Medical Physics Unit, McGill University Health Centre and Department of Oncology, McGill University, Montréal, Québec, Canada., Département de physique, de génie physique et d'optique et Centre de recherche sur le cancer, Université Laval, Québec, Canada; Département de radio-oncologie et CRCHU de Québec, CHU de Québec, Québec, Canada. Electronic address: .