The aim of this study is to determine which cancer and demographic criteria influence the indication for surgery (radical prostatectomy) or radiation therapy (external or brachytherapy) in the treatment of prostate cancer.
An analysis of the 2714 patients of the 2010 National Prostate Cancer Registry treated with curative intent. The analysed variables were age, prostate-specific antigen (PSA), prostate volume, the number of biopsy cores, the percentage of positive cores, the stage, Gleason score, the type of pathologist, the presence of perineural invasion and the study centre. We analysed the association among these variables and the type of treatment (surgery vs. radiation therapy/brachytherapy), using a univariate analysis (Student's t test and chi-squared) and a binary multiple logistic regression.
The 48.12% of the patients (1306/2714) were treated with surgery, and 51.88% (1,408/2,714) underwent radiation therapy/brachytherapy. Differences were observed between the patients treated with prostatectomy and those treated with radiation therapy/brachytherapy (p<.05) in age (63.50±6.5 vs. 69.0±6.7), PSA (8.76±16.97 vs. 13.21±15.88), biopsied cores, percentage of positives cores (30.0±22 vs. 38.7±29), Gleason score (G6: 53.9% vs. 46.1%; G7: 45% vs. 55% G8-10: 26.6%, 73.4%), stage (localised: 50% vs. 50%; locally advanced: 14.6% vs. 85.4%), perineural invasion and hospital centre. In the multivariate analysis, the selected independent variables were age, PSA, percentage of positives cores, stage, Gleason score and hospital centre.
According to our study, age, tumour aggressiveness and stage and the centre where the patient will be treated affect the selection of curative treatment for prostate cancer.
Actas urologicas espanolas. 2016 May 31 [Epub ahead of print]
J M Martínez-Jabaloyas, A Castelló-Porcar, A C González-Baena, J M Cózar-Olmo, B Miñana-López, F Gómez-Veiga, A Rodriguez-Antolín, Grupo Español de Cáncer de Próstata
Servicio de Urología, Hospital Clínico Universitario, Valencia, España. Electronic address: ., Servicio de Urología, Hospital Clínico Universitario, Valencia, España., Servicio de Urología, Hospital Virgen de la Macarena, Sevilla, España., Servicio de Urología, Hospital Virgen de las Nieves, Granada, España., Servicio de Urología, Hospital Morales Meseguer, Murcia, España., Servicio de Urología, C.H.U.A.C., Hospital Universitario de Salamanca, Salamanca, España., Servicio de Urología, Hospital Gregorio Marañón, Madrid, España.