Fatal hepatocellular carcinoma presenting with oral metastasis in a patient with synchronic primary malignancies of prostate and liver.

Hepatocellular carcinoma (HCC) is the most frequent type of liver cancer and its occurrence in the oral cavity as a metastatic neoplasm is a rare event. We describe a fatal case of HCC with oral metastasis in a patient firstly diagnosed with prostatic and hepatic carcinomas. The histopathological examination revealed a hepatocyte-like tumour cells arranged in organoid structures as well as positivity to cytokeratin 8 and Hep Par 1. The present findings highlight the importance of a complete medical evaluation of the patient to identify possible oral repercussions of primary diseases.

Gerodontology. 2016 May 21 [Epub ahead of print]

Maria Fernanda Setúbal Destro Rodrigues, Carina Magalhães Esteves, Márcio Augusto de Oliveira, Nathália Paiva de Andrade, Bruno Tavares Sedassari, Fernando Augusto Soares, Fabio Daumas Nunes

Laboratory of Molecular Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil., Laboratory of Molecular Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil., Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil., Laboratory of Molecular Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil., Laboratory of Surgical Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil., General Pathology, Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.