One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology.
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Here we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.
Endocrine-related cancer. 2016 Apr 29 [Epub ahead of print]
Lisa M Butler, Margaret M Centenera, Johannes V Swinnen
L Butler, School of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, Australia., M Centenera, School of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, Australia., J Swinnen, Department of Oncology, KU Leuven - University of Leuven, Leuven, Belgium