OBJECTIVES - To report the incidence of prostate cancer diagnosis and quality of life outcomes following transperineal prostate biopsy.
METHODS - Forty six consecutive patients underwent office-based transperineal prostate biopsy for an elevated PSA and a normal DRE without prior prostate biopsy.
Prior to biopsy, a repeat PSA was obtained to ensure persistent elevation. Silodosin (8mg daily) was initiated the day prior to biopsy and continued for one week. Eighteen-twenty biopsy cores were obtained per patient. All patients responded to a visual analog scale (VAS) ranging from 0-10 immediately following the completion of both the local anesthesia and the biopsy procedure. In addition, an IPSS, R-FAS, IIEF, CES-D and PVR were obtained at baseline and 30 days following biopsy except IPSS which was also obtained at day 7.
RESULTS - The mean patient age was 63.3 years with a mean prostate volume of 41.8 cm(3). The mean VAS was 4.2 for the local anesthesia and 3.0 for the biopsy. Thirty one patients (67.4%) were diagnosed with prostate cancer with eighteen having a Gleason score > 7. Compared to baseline, no adverse changes in IPSS, R-FAS, IIEF, CES-D or PVR were detected at day 30. No patient required catheterization, developed sepsis or required hospitalization.
CONCLUSIONS - Office-based transperineal prostate biopsy was well tolerated with reasonable treatment related discomfort, a high rate of prostate cancer diagnosis, and the absence of significant morbidity including sepsis.
Urology. 2016 Apr 26 [Epub ahead of print]
Gregory Merrick, Sarah Irvin, Ryan Fiano, Richard Anderson, Wayne M Butler, Edward Adamovich
Schiffler Cancer Center, Wheeling Jesuit University Department of Urology, Wheeling, WV; Wheeling Hospital, Wheeling Jesuit University Department of Urology, Wheeling, WV. Schiffler Cancer Center, Wheeling Jesuit University Department of Urology, Wheeling, WV., Schiffler Cancer Center, Wheeling Jesuit University Department of Urology, Wheeling, WV., Schiffler Cancer Center, Wheeling Jesuit University Department of Urology, Wheeling, WV., Schiffler Cancer Center, Wheeling Jesuit University Department of Urology, Wheeling, WV., Wheeling Hospital, Department of Pathology, Wheeling, WV.