Prognosis of Castration-resistant Prostate Cancer Patients - Use of the AdnaTest® System for Detection of Circulating Tumor Cells.

Detection of circulating tumor cells (CTC) in patients with castration-resistant prostate cancer (CRPC) may improve the estimate of chemotherapy response. We evaluated the AdnaTest® system in patients receiving docetaxel.

CTC analysis was carried out in 37 patients by immunomagnetic separation. Correlation between serum prostate-specific antigen (sPSA) change and CTC presence and the influence of each parameter on the overall survival (OS) were evaluated.

We detected CTCs in 32 and 16 patients before and after three docetaxel cycles, respectively. The sPSA level correlated with CTC positivity during docetaxel therapy (p=0.0031). The longest OS was in patients negative for CTCs in both samples (p=0.0228). Change in sPSA levels was associated with treatment response (p=0.033).

We detected CTCs in a considerable number of patients with CRPC. The absolute change of sPSA level correlated with OS. CTC presence during docetaxel therapy was associated with shorter OS.

Anticancer research. 2016 Apr [Epub]

Otakar Čapoun, Veronika Mikulová, Markéta Jančíková, Hana Honová, Katarína Kološtová, Roman Sobotka, Pešl Michael, Tomáš Zima, Tomáš Hanuš, Viktor Soukup

Department of Urology, General University Hospital and of The First Faculty of Medicine of Charles University ., Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and of The First Faculty of Medicine of Charles University., Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and of The First Faculty of Medicine of Charles University., Department of Oncology, General University Hospital and of The First Faculty of Medicine of Charles University., Department of Tumor Biology, Third Faculty of Medicine, Charles University, Prague, Czech Republic., Department of Urology, General University Hospital and of The First Faculty of Medicine of Charles University., Department of Urology, General University Hospital and of The First Faculty of Medicine of Charles University., Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and of The First Faculty of Medicine of Charles University., Department of Urology, General University Hospital and of The First Faculty of Medicine of Charles University., Department of Urology, General University Hospital and of The First Faculty of Medicine of Charles University.

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