Is Prostate Cancer Incidence Worldwide Linked to Artificial Light at Night Exposures? Earlier Findings' Revisit and Current Trends' Analysis.

Widespread use of artificial light at night (ALAN) might contribute to the global burden of hormone-dependent cancers. However, previous attempts to verify this association in population-level studies have been sparse.

Using the GLOBOCAN, US-DMSP and World Bank's 2010-2012 databases, we studied the association between ALAN and prostate cancer (PC) incidence in 180 countries worldwide, controlling for several country-level confounders. As our analysis indicates, the PC-ALAN association emerged marginally significant when year-2012 PC age-standardized rate data were compared with ALAN levels (t = 1.886, P<0.1); while this association emerged as more significant (t>2.7; P<0.01) when only 110 countries with well-maintained cancer registries were analyzed. Along with other variables, ALAN explains up to 79% of PC ASRs variability. PC-ALAN association appears to vary regionally, with the greatest deviations in Central Africa, Small Island Developing States, South East Asia and Gulf States.

Archives of environmental & occupational health. 2016 Mar 30 [Epub ahead of print]

Nataliya A Rybnikova, Abraham Haim, Boris A Portnova

a Department of Natural Resources and Environmental Management, Faculty of Management, University of Haifa, 31805, Carmel, Mt, Israel ., b The Israeli Center for Interdisciplinary  Research in Chronobiology, University of Haifa, 31905 , Mount Carmel , Israel ., a Department of Natural Resources and Environmental Management, Faculty of Management, University of Haifa, 31805, Carmel, Mt, Israel .