Prostate cancer: from Gleason scoring to prognostic grade grouping.

The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to prognosis, the application of the Gleason grading system changed substantially in surgical pathology.

First in 2005 and more recently in 2014, consensus conferences were held to update PAC grading. Here, we review of the successive changes in the grading of PAC from the original system, with emphasis on the newest prognostic grade grouping.

Expert review of anticancer therapy. 2016 Apr [Epub]

Rodolfo Montironi, Matteo Santoni, Roberta Mazzucchelli, Luciano Burattini, Rossana Berardi, Andrea B Galosi, Liang Cheng, Antonio Lopez-Beltran, Alberto Briganti, Francesco Montorsi, Marina Scarpelli

a Section of Pathological Anatomy , Polytechnic University of the Marche Region, School of Medicine, United Hospitals , Ancona , Italy., b Clinica di Oncologia Medica, AOU Ospedali Riuniti , Polytechnic University of the Marche Region , Ancona , Italy., a Section of Pathological Anatomy , Polytechnic University of the Marche Region, School of Medicine, United Hospitals , Ancona , Italy., b Clinica di Oncologia Medica, AOU Ospedali Riuniti , Polytechnic University of the Marche Region , Ancona , Italy., b Clinica di Oncologia Medica, AOU Ospedali Riuniti , Polytechnic University of the Marche Region , Ancona , Italy., c Urology Clinic , Polytechnic University of the Marche Region, School of Medicine , Ancona , Italy., d Department of Pathology and Laboratory Medicine , Indiana University School of Medicine , Indianapolis , IN , USA., e Pathology Service , Champalimaud Clinical Center , Lisbon , Portugal., f Unit of Urology/Division of Oncology , URI, IRCCS Ospedale San Raffaele , Milan , Italy., f Unit of Urology/Division of Oncology , URI, IRCCS Ospedale San Raffaele , Milan , Italy., a Section of Pathological Anatomy , Polytechnic University of the Marche Region, School of Medicine, United Hospitals , Ancona , Italy.

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