Steroid co-introduction with docetaxel chemotherapy for metastatic castration-resistant prostate cancer affects PSA flare.

OBJECTIVE - To investigate the potential relationship of steroid usage with prostate-specific antigen (PSA) flare and the prognostic impact of PSA flare, which is known to occur in 10-20% of patients with metastatic castration-resistant prostate cancer during docetaxel chemotherapy.

METHODS - This study included 71 patients with metastatic castration-resistant prostate cancer treated by docetaxel chemotherapy with co-introduction of steroid. PSA flare was defined as transient PSA increase followed by PSA decrease.

RESULTS - PSA flare was recognized in 7.0-23.9% of patients according to various definitions. Intriguingly, men with steroid intake before the initiation of docetaxel chemotherapy experienced significantly fewer PSA flares. The progression-free survival rate in men with PSA flare was equivalent to that of PSA responders, but significantly better than men with PSA failure.

CONCLUSIONS - Our results suggest that de novo steroid co-introduction with docetaxel chemotherapy induce the PSA flare phenomenon. This novel finding may account for the mechanism of PSA flare as well as being valuable for distinguishing PSA elevation as PSA flare or failure. This article is protected by copyright. All rights reserved.

BJU international. 2016 Mar 17 [Epub ahead of print]

Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Keijiro Kiyoshima, Junichi Inokuchi, Katsunori Tatsugami, Ken-Ichiro Shiga, Hirofumi Koga, Akito Yamaguchi, Seiji Naito, Masatoshi Eto

Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Division of Urology, Harasanshin Hospital, Fukuoka, Japan., Division of Urology, Harasanshin Hospital, Fukuoka, Japan., Division of Urology, Harasanshin Hospital, Fukuoka, Japan., Division of Urology, Harasanshin Hospital, Fukuoka, Japan., Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.